Retargeting adenoviruses for therapeutic applications and vaccines.

Michael A BarryJeffrey D RubinShao-Chia Lu

Published in: FEBS letters (2020)

Adenoviruses (Ads) are robust vectors for therapeutic applications and vaccines, but their use can be limited by differences in their in vitro and in vivo pharmacologies. This review emphasizes that there is not just one Ad, but a whole virome of diverse viruses that can be used as therapeutics. It discusses that true vector targeting involves not only retargeting viruses, but importantly also detargeting the viruses from off-target cells.

Keyphrases

induced apoptosis
cell cycle arrest
small molecule
oxidative stress
cell death