Atractylenolide I ameliorates cancer cachexia through inhibiting biogenesis of IL-6 and tumour-derived extracellular vesicles.

Meng Fan Xiaofan Gu Wanli Zhang Xiong-Wen Zhang Ruiqin Zhang Qiaoyu Fang Yueping Wang Xiaodong Guo Xiong-Wen Zhang Xuan Liu

Published in: Journal of cachexia, sarcopenia and muscle (2022)

AI ameliorates cancer cachexia by decreasing the production of IL-6 and EVs of tumour cells. The decreasing effects of AI on EVs biogenesis are based on its inhibition on STAT3/PKM2/SNAP23 pathway.

Keyphrases

papillary thyroid
squamous cell
induced apoptosis
artificial intelligence
mouse model
signaling pathway
cell cycle arrest
squamous cell carcinoma
lymph node metastasis
oxidative stress
endoplasmic reticulum stress
pi k akt