GC-MS Analysis, Antioxidant and Antifungal Studies of Different Extracts of Chaetomium globosum Isolated from Urginea indica .

To discover new natural resources with biological effects, the chemical investigation of antioxidant and antimicrobial activities of extract's Chaetomium globosum isolated from roots of Urginea indica . Gas chromatography-mass spectrometry (GC-MS) analysis demonstrated the presence of the major chemical constituents present in the methanol extract (1,3-oxathiolane, 1,3-cyclopentadiene, 5-(1-methylethylidene), 5,9-hexadecadienoic acid, methyl ester, decane), chloroform extract (acetic acid, diethoxy-, ethyl ester, 2,2-bis(ethylsulfonyl)propane, 3-methyl-2-(2-oxopropyl) furan), and hexane extract (3-hexanone, 4,4-dimethyl, decane,2,6-dimethyldecane, decane, 2,4,6-trimethyl, decane, 2,4,6-trimethyl, 1-butanesulfinamide, 1,1,2,2,3,3,4,4,4-nonafluoro-N-methyl, decane). The total compound identified (56.2%) in chloroform extract, (54.72%) in hexane extract, and (65%) in methanol extract. The antioxidant effects were performed using diphenylpicrylhydrazyl radical (DPPH). The results showed that the methanol extract showed significantly the highest anti-DPPH with an IC 50 value of 37.61 ± 1.37  μ g/mL, followed by chloroform and hexane extracts with IC 50 values of 40.82 ± 3.60 and 45.20 ± 2.54  μ g/mL, respectively. The antifungal activity of extracts was evaluated against pathogens fungi including Fusarium oxysporum , Rosellinia necatrix , Cladosporium xanthochromaticum , and Sclerotinia sclerotiorum . Methanolic and chloroform extracts showed maximum inhibition against all test pathogens, while hexane extract showed minimum inhibition.