Macrophages Impair TLR9 Agonist Antitumor Activity through Interacting with the Anti-PD-1 Antibody Fc Domain.
Simone CamellitiValentino Le NociFrancesca BianchiChiara StortiFrancesca ArnaboldiAlessandra CataldoSerena IndinoElena JachettiAlessandro Massimo GianniMario Paolo ColomboAndrea BalsariNicoletta GaglianoElda TagliabueLucia SfondriniMichele SommarivaPublished in: Cancers (2021)
Our data suggest that if TLR signaling is active in macrophages, coadministration of an anti-PD-1 antibody can reprogram these immune cells towards a polarization state able to negatively affect the immune response and eventually promote tumor growth.