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Macrophages Impair TLR9 Agonist Antitumor Activity through Interacting with the Anti-PD-1 Antibody Fc Domain.

Simone CamellitiValentino Le NociFrancesca BianchiChiara StortiFrancesca ArnaboldiAlessandra CataldoSerena IndinoElena JachettiAlessandro Massimo GianniMario Paolo ColomboAndrea BalsariNicoletta GaglianoElda TagliabueLucia SfondriniMichele Sommariva
Published in: Cancers (2021)
Our data suggest that if TLR signaling is active in macrophages, coadministration of an anti-PD-1 antibody can reprogram these immune cells towards a polarization state able to negatively affect the immune response and eventually promote tumor growth.
Keyphrases
  • immune response
  • toll like receptor
  • inflammatory response
  • dendritic cells
  • nuclear factor
  • electronic health record
  • big data
  • protein kinase