Tuna Bone Powder Alleviates Glucocorticoid-Induced Osteoporosis via Coregulation of the NF-κB and Wnt/β-Catenin Signaling Pathways and Modulation of Gut Microbiota Composition and Metabolism.
Jingjing LiMingyuan YangChenyang LuJiaojiao HanShasha TangJun ZhouYe LiTinghong MingZaijie Jim WangXiurong SuPublished in: Molecular nutrition & food research (2020)
These data show that TBP ameliorates GIOP in mice through four aspects, including coregulating signaling pathways, blocking proinflammatory cytokines, repairing the intestinal epithelial barrier, and modulating gut microbiota. Therefore, TBP may be a potential prebiotic agent to alleviate osteoporosis in humans.
Keyphrases
- signaling pathway
- bone mineral density
- postmenopausal women
- epithelial mesenchymal transition
- pi k akt
- cell proliferation
- induced apoptosis
- body composition
- high glucose
- mouse model
- diabetic rats
- stem cells
- electronic health record
- high fat diet induced
- big data
- oxidative stress
- endothelial cells
- soft tissue
- metabolic syndrome
- risk assessment
- wild type
- climate change
- artificial intelligence
- stress induced