Ultrasmall Fe(III)-Tannic Acid Nanoparticles To Prevent Progression of Atherosclerotic Plaques.
Dan MuWenshen WangJianhui LiPin LvRenyuan LiuYing TanChongxia ZhongYu QiXuan SunYihai LiuSong ShenYuyu LiBiao XuBing ZhangPublished in: ACS applied materials & interfaces (2021)
Macrophage accumulation is central to the pathogenesis of atherosclerotic plaques. Reducing macrophages in plaques is an appealing approach to attenuate the development of atherosclerosis. Chemodynamic therapy, specifically inhibiting hydrogen peroxide (H2O2)-rich cells in slightly acidic microenvironment, has emerged as a new method in tumor treatment. Herein, we manufactured ultrasmall dopamine-modified hyaluronic acid (HD)-stabilized Fe(III)-tannic acid nanoparticles (HFTNPs). HFTNPs can specifically accumulate in inflammatory macrophages in atherosclerotic plaques, provide brighter magnetic resonance images, promote reactive oxygen species (ROS) generation, and induce the death of inflammatory macrophages without damaging normal cells and tissues. In conclusion, HFTNPs have a tremendous potential as safe and effective diagnostic and therapeutic reagents for atherosclerosis.
Keyphrases
- hydrogen peroxide
- induced apoptosis
- reactive oxygen species
- hyaluronic acid
- magnetic resonance
- cell cycle arrest
- oxidative stress
- cardiovascular disease
- signaling pathway
- stem cells
- cell death
- nitric oxide
- dna damage
- metabolic syndrome
- computed tomography
- uric acid
- climate change
- metal organic framework
- ionic liquid
- pi k akt
- convolutional neural network
- replacement therapy