Aberrantly activated Wnt/β-catenin pathway co-receptors LRP5 and LRP6 regulate osteoblast differentiation in the developing coronal sutures of an Apert syndrome (Fgfr2S252W /+ ) mouse model.
Nay Myo Min SweYukiho KobayashiHiroyuki KamimotoKeiji MoriyamaPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2020)
The Wnt/β-catenin pathway was activated in the CS of Fgfr2S252W/+ mice during craniofacial development, suggesting the involvement of the Wnt/β-catenin pathway in the pathogenesis of CS synostosis in Fgfr2S252W/+ mice.