Regulator of G-protein signaling 14 protects the liver from ischemia-reperfusion injury by suppressing TGF-β-activated kinase 1 activation.

Jia-Kai ZhangMing-Jie DingHui LiuJi-Hua ShiZhi-Hui WangPei-Hao WenYi ZhangBing YanDan-Feng GuoXiao-Dan ZhangRuo-Lin TaoZhi-Ping YanYan ZhangZhen LiuWen-Zhi GuoShui-Jun Zhang

Published in: Hepatology (Baltimore, Md.) (2021)

RGS14 plays a protective role in hepatic IR by inhibiting activation of the TAK1-JNK/p38 signaling pathway. This may be a potential therapeutic strategy for reducing incidences of hepatic IRI in the future.

Keyphrases

signaling pathway
ischemia reperfusion injury
pi k akt
induced apoptosis
epithelial mesenchymal transition
oxidative stress
transforming growth factor
cell death
endoplasmic reticulum stress
cell proliferation