Systematic review of sarcopenia in chronic pancreatitis: prevalence, impact on surgical outcomes, and survival.
James BundredRohan G ThakkarSanjay PandanaboyanaPublished in: Expert review of gastroenterology & hepatology (2022)
In total, nine studies reported on 977 patients with a sarcopenia prevalence of 32.3% (95% CI 22.9-42.6%). CT remains the primary modality to assess for sarcopenia, due to ease of access. None of the studies reporting on post-operative outcomes for patients with chronic pancreatitis found a significant increase in complications among those with sarcopenia. Mortality within 1 year in the outpatient setting from one study of patients with CP was 16% in sarcopenic patients versus 3% (HR: 6.69 (95% CI: 1.79-24.9), p < 0.001) in those with no sarcopenia.Sarcopenia is prevalent in patients with CP occurring in approximately a third of patients. Sarcopenia is associated with an adverse impact on long-term survival.
Keyphrases
- emergency department
- skeletal muscle
- systematic review
- end stage renal disease
- risk factors
- ejection fraction
- newly diagnosed
- community dwelling
- chronic kidney disease
- magnetic resonance imaging
- type diabetes
- cardiovascular disease
- patient reported outcomes
- metabolic syndrome
- adipose tissue
- cardiovascular events
- pet ct
- image quality
- electronic health record