Role of the arecoline/YAP1/BMP4 pathway in promoting endothelial-mesenchymal transition in oral submucous fibrosis.

Mianfeng YaoJiang LiShanshan YuanXilei ZhuZijie HuQiulan LiRuoyan CaoWenjin WangChang-Yun Fang

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2019)

Arecoline induces EMT in OSF via the YAP1/BMP4 pathway. Thus, BMP4 could be considered as a potential therapeutic target for the treatment of OSF.

Keyphrases

mesenchymal stem cells
bone regeneration
bone marrow
stem cells
epithelial mesenchymal transition
endothelial cells
human health
risk assessment
signaling pathway
liver fibrosis
replacement therapy