Ginsenoside Rg3 inhibits angiogenesis in a rat model of endometriosis through the VEGFR-2-mediated PI3K/Akt/mTOR signaling pathway.

Yang CaoQing YeMengfei ZhuangShuwu XieRuihua ZhongJingang CuiJieyun ZhouYan ZhuTingting ZhangLin Cao

Published in: PloS one (2017)

The present study demonstrates, for the first time, that ginsenoside Rg3 suppresses angiogenesis in developing endometrial lesions. The ginsenoside Rg3 inhibitory effect on the growth of the ectopic endometrium in EMs rats might occur through the blocking of the VEGFR-2-mediated PI3K/Akt/mTOR signaling pathway, thus halting angiogenesis and promoting the apoptosis of ectopic endometrial cells.

Keyphrases

signaling pathway
vascular endothelial growth factor
cell cycle arrest
induced apoptosis
pi k akt
endothelial cells
endoplasmic reticulum stress
oxidative stress
epithelial mesenchymal transition
cell death
wound healing
endometrial cancer
cell proliferation