MUC1-C Dictates JUN and BAF-Mediated Chromatin Remodeling at Enhancer Signatures in Cancer Stem Cells.
Atrayee BhattacharyaAtsushi FushimiNami YamashitaMasayuki HagiwaraYoshihiro MorimotoHasan RajabiMark D LongMaha AbdullaRehan AhmadKelly StreetSong LiuTao LiuDonald W KufePublished in: Molecular cancer research : MCR (2022)
These findings show that MUC1-C, which is necessary for the CRPC and TNBC CSC state, activates a novel pathway involving JUN/AP-1 and ARID1A/BAF that regulates chromatin accessibility of stemness-associated gene enhancers.