Effects and sites of action of a M1 receptor positive allosteric modulator on colonic motility in rats and dogs compared with 5-HT4 agonism and cholinesterase inhibition.
Yasuhiro TsukimiRuslan V PustovitAndrea M HarringtonSonia Garcia-CaraballoStuart M BrierleyMadeleine Di NataleJuan C MoleroJohn Barton FurnessPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)
These results suggest that M1PAMs produce highly coordinated propagating contraction by actions on the enteric nervous system of the colon. The localization of M1R to enteric neurons in both animals and humans suggests that the M1PAM effects would be translatable to human. M1PAMs provide a potential novel therapeutic option for constipation disorders.