The Cytoprotective Effect of C60 Derivatives in the Self-Microemulsifying Drug Delivery System against Triptolide-Induced Cytotoxicity In Vitro.

Beihua XuZhenyu WangHuimin ZhangXiao XuMengjie TangGang WangZhongpeng DingRuihao YuMeihong DingTing ZhangSenlin Shi

Published in: Molecules (Basel, Switzerland) (2024)

The cytoprotection provided by the C60-SMEDDS/TP favored normal cells (L02 and GES-1) over tumor cells (BEL-7402 and HepG2 cells) in vitro. This suggests a promising approach for the safe and effective treatment of TP.

Keyphrases

induced apoptosis
cell cycle arrest
high glucose
drug induced
endothelial cells
combination therapy
structure activity relationship