Orphan Nuclear Receptor NR4A3 Promotes Vascular Calcification via Histone Lactylation.

Wenqi MaKangni Jia Haomai Cheng Hong XuZhigang LiHang ZhangHongyang Xie Hang Sun Lei YiZhiyong ChenShengzhong DuanMotoaki Sano Keiichi Fukuda Lin Lu Yu Jie Zhou Ruiyan Zhang Xiaoxiang Yan

Published in: Circulation research (2024)

Taken together, our findings reveal that NR4A3-mediated histone lactylation is a novel metabolome-epigenome signaling cascade mechanism that participates in the pathogenesis of medial arterial calcification.

Keyphrases

dna methylation
genome wide
chronic kidney disease
gene expression
single cell
binding protein