Diffuse large B cell lymphoma secondary to JC virus in progressive multifocal leukoencephalopathy.
Ashwin ReddiNikhil PatelNicholas A MorrisPublished in: Journal of neurovirology (2019)
We present the case of a 43-year-old-man with a past medical history of HIV with recently initiated HAART and existing PML that presented with altered mental status. The initial diagnosis was deemed to be PML-IRIS; however, neuroimaging brought into question this diagnosis. Flow cytometry performed from the cerebrospinal fluid revealed diffuse large B cell lymphoma. JC virus may act in an oncogenic role similarly to EBV and predispose to CNS lymphomas. Patients with PML caused by JC virus may develop secondary malignancies.
Keyphrases
- diffuse large b cell lymphoma
- epstein barr virus
- flow cytometry
- cerebrospinal fluid
- antiretroviral therapy
- healthcare
- hiv infected
- human immunodeficiency virus
- multiple sclerosis
- hiv positive
- mental health
- transcription factor
- disease virus
- hiv infected patients
- hiv aids
- blood brain barrier
- men who have sex with men