First trimester metabolomics 1H-NMR study of the urinary profile predicts gestational diabetes mellitus development in obese women.
Cristina PirasIsabella NeriRoberta PintusAntonio NotoElisabetta PetrellaFrancesca MonariAngelica DessìVassilios FanosLuigi AtzoriFabio FacchinettiPublished in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2021)
In a prevalently Caucasian population, the changes of some metabolites such as tryptophan, trigonelline, and branch-chained amino acids in the urinary profile of obese women in the first trimester are able to make unequivocal prediction of those which later test positive for GDM. This approach could be useful to diagnose much earlier obese women with GDM allowing lifestyle counselling and other interventions.
Keyphrases
- weight loss
- metabolic syndrome
- adipose tissue
- pregnancy outcomes
- polycystic ovary syndrome
- obese patients
- bariatric surgery
- type diabetes
- physical activity
- magnetic resonance
- pregnant women
- mass spectrometry
- high resolution
- cervical cancer screening
- smoking cessation
- human immunodeficiency virus
- skeletal muscle
- hiv testing