Autoimmunity Against Surfactant Protein B Is Associated with Pneumonitis During Checkpoint Blockade.
Nina WyssFiamma BernerVincent WalterAnn-Kristin JochumMette T PurdeMarie-Therese AbdouTobias SinnbergKathrin HofmeisterOltin T PopOmar Hasan AliJens BauerHung-Wei ChengMechthild LütgeNiklas KlümperStefan DiemZeynep Kosaloglu-YalcinYizheng ZhangLaura SellmerBoris MacekJulia KarbachDavid KönigHeinz LäubliLars ZenderBritta S MeyerChristoph DriessenChristian M SchürchWolfram JochumTeresa AmaralLucie HeinzerlingAntonio CozzioAhmed N HegazyTino SchneiderMartin H BrutscheAlessandro SetteTobias L LenzJuliane WalzHans-Georg RammenseeMartin FrühElke JägerBurkhard BecherAmanda TufmanNicolas NuñezMarkus JoergerLukas FlatzPublished in: American journal of respiratory and critical care medicine (2024)
T cells is associated with the development of pneumonitis during ICI therapy. Pre-treatment levels of these antibodies may represent a potential biomarker for elevated risk of developing pneumonitis and on-treatment levels may provide a diagnostic aid. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).