Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners.
Albert RosenbergerRayjean J HungDavid C ChristianiNeil E CaporasoGeoffrey LiuStig E BojesenLoic Le MarchandCh A HaimanDemetrios AlbanesMelinda C AldrichAdonina TardonG Fernández-TardónGad RennertJohn K FieldB KiemeneyPhilip LazarusAage HaugenShanbeh ZienolddinyStephen LamMatthew B SchabathAngeline S AndrewHans BrunnsstömGary E GoodmanJennifer A DohertyChu ChenM Dawn TeareH-Erich WichmannJudith ManzAngela RischThomas R MuleyMikael JohanssonPaul BrennanMaria Teresa LandiChristopher I AmosBeate PeschGeorg JohnenThomas BrüningHeike BickeböllerMaria GomolkaPublished in: International archives of occupational and environmental health (2018)
The well-established association of the genomic region 15q25 to lung cancer might be influenced by exposure to radon among uranium miners. Furthermore, lung cancer susceptibility is related to the functional capability of DNA damage signaling via ubiquitination processes and repair of radiation-induced double-strand breaks by the single-strand annealing mechanism.