DNA Methylation Demonstrates Bronchoalveolar Cell Senescence in People Living with HIV: An Observational Cohort Study.
Ana I Hernandez CorderoXuan LiJulia YangChen Xi YangTawimas ShaipanichJulie L MacIsaacKristy DeverMichael S KoborJulio MontanerMarianne HarrisSilvia GuillemiShu Fan Paul ManDon D SinJanice M LeungPublished in: Biomedicines (2024)
We have shown here for the first time that alterations in the DNA methylation of BAL cells in the lung with HIV show a pattern of advanced aging. This study strongly supports that HIV may contribute to an increased the risk of lung comorbidities through the epigenetics of aging.
Keyphrases
- dna methylation
- antiretroviral therapy
- hiv positive
- hiv testing
- hiv infected
- human immunodeficiency virus
- hepatitis c virus
- genome wide
- hiv aids
- induced apoptosis
- men who have sex with men
- gene expression
- cell cycle arrest
- single cell
- endothelial cells
- cell therapy
- endoplasmic reticulum stress
- oxidative stress
- stress induced
- cell proliferation