Blood Pressure, Antihypertensive Use, and Late-Life Alzheimer and Non-Alzheimer Dementia Risk: An Individual Participant Data Meta-Analysis.
Matthew Joseph LennonDarren M LipnickiBen Chun Pan LamJohn D CrawfordAletta E SchutteRuth PetersTherese Rydberg-SternerJenna NajarIngmar SkoogSteffi G Riedel-HellerSusanne RöhrAlexander PabstAntonio LoboConcepción De-la-CámaraElena LoboRichard B LiptonMindy J KatzCarol A DerbyKi Woong KimJi Won HanDae Jong OhElena RolandiAnnalisa DavinMichele RossiNikolaos ScarmeasMary YannakouliaEfthimios DardiotisHugh C HendrieSujuan GaoIsabelle CarriereKaren RitchieKaarin Jane AnsteyNicolas CherbuinShifu XiaoLing YueWei LiMaëlenn GuerchetPierre-Marie PreuxVictor AboyansMary N HaanAllison AielloMarcia ScazufcaPerminder Singh Sachdevnull nullPublished in: Neurology (2024)
Antihypertensive use was associated with decreased AD but not non-AD risk throughout late life. This suggests that treating hypertension throughout late life continues to be crucial in AD risk mitigation. A single measure of BP was not associated with AD risk, but DBP may have a U-shaped relationship with non-AD risk over longer periods in late life.