Brain Age Gap in Early Illness Schizophrenia and the Clinical High-Risk Syndrome: Associations With Experiential Negative Symptoms and Conversion to Psychosis.
Jessica P Y HuaSamantha V AbramRachel L LoewyBarbara StuartSusanna L FryerSophia VinogradovDaniel H MathalonPublished in: Schizophrenia bulletin (2024)
Consistent with schizophrenia pathophysiological models positing abnormal brain maturation, results suggest abnormal brain development is present early in psychosis. An increased brain age gap may be especially relevant to motivational and functional deficits in schizophrenia.