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The association between silica exposure, silicosis and tuberculosis: a systematic review and meta-analysis.

Rodney I EhrlichPaula AkugizibweNandi SiegfriedDavid Rees
Published in: BMC public health (2021)
The evidence is robust for a strongly elevated risk of tuberculosis with radiological silicosis, with a low disease severity threshold. The effect estimate is more uncertain for silica exposure without radiological silicosis. Research is needed, particularly cohort studies measuring silica exposure in different settings, to characterise the effect more accurately as well as the silica exposure threshold that could be used to prevent excess tuberculosis risk.
Keyphrases
  • mycobacterium tuberculosis
  • pulmonary tuberculosis
  • hiv aids
  • adverse drug
  • antiretroviral therapy
  • electronic health record