Natural Killer Cell Dysfunction in Premenopausal BRCA1 Mutation Carriers: A Potential Mechanism for Ovarian Carcinogenesis.
Shaun HaranKantaraja ChinderaMay SabryNafisa WilkinsonRupali AroraAgnieszka ZubiakThomas E BartlettIona EvansAllison JonesDaniel ReiselChiara HerzogTwana AlkasaliasMark NewmanJaeyeon KimAngelique Flöter RådestadKristina Gemzell-DanielssonAdam N RosenthalLouis DubeauMark W LowdellMartin WidschwendterPublished in: Cancers (2024)
mutation carriers, either systemically or locally, may favor site-specific pre-invasive carcinogenesis. These cumulative effects across a reproductive lifecycle in high-risk carriers can have a detrimental effect further supporting epidemiological evidence for ovulation inhibition.