Higher sensitivity and accuracy of synovial next-generation sequencing in comparison to culture in diagnosing periprosthetic joint infection: a systematic review and meta-analysis.

Ashraf T HantoulyOsama AlzobiAhmad A ToubasiBashir ZikriaMohammed Al Ateeq Al DosariGhalib Ahmed Alhaneedi

Published in: Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA (2022)

NGS has a potential role in diagnosing hip and knee PJIs due to its high sensitivity, specificity, and accuracy. However, the sensitivity and specificity reported by the studies varied according to the time of synovial sampling (preoperative, postoperative, or mixed).

Keyphrases

patients undergoing
structural basis
total hip
total hip arthroplasty
gene expression
circulating tumor