Matrix Metalloproteinase Genes (MMP1, MMP10, MMP12) on Chromosome 11q22 and the Risk of Non-Contact Anterior Cruciate Ligament Ruptures.

Ewelina LulińskaAndrea GibbonMariusz KaczmarczykAgnieszka Maciejewska-SkrendoKrzysztof FicekAgata Leońska-DuniecMichał WilkKatarzyna LeźnickaMonika Michałowska-SawczynKinga Humińska-LisowskaRafał BurytaPaweł Cieszczyk Ewelina Maculewicz Wojciech CzarnyAlison V SeptemberMarek Sawczuk

Published in: Genes (2020)

Despite the fact that the current study did not support existing evidence suggesting that variants within the MMP1, MMP10, and MMP12 genes influence non-contact ACL rupture risk, future work should include high-throughput sequencing technologies to identify potential targeted polymorphisms to fully characterize the 11q22 region with susceptibility to non-contact ACL rupture susceptibility in a Polish cohort.

Keyphrases

cell migration
anterior cruciate ligament
high throughput sequencing
risk assessment
cancer therapy