Rac1/ROCK-driven membrane dynamics promote natural killer cell cytotoxicity via granzyme-induced necroptosis.

Yanting ZhuJun XieJue Shi

Published in: BMC biology (2021)

Our results not only elucidate a new NK cell effector mechanism but also suggest that tissue microenvironment and oncogenic signaling pathways that promote membrane dynamics, e.g., Rac1 and Rho/ROCK, could be exploited to enhance proinflammatory NK cell killing.

Keyphrases

nk cells
signaling pathway
single cell
stem cells
high glucose
diabetic rats
cell migration
cell therapy
transcription factor
regulatory t cells
dendritic cells
drug induced
protein kinase
epithelial mesenchymal transition
cell proliferation
smooth muscle
type iii