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Malignancy in Renal Transplant Recipients Exposed to Cyclophosphamide Prior to Transplantation for the Treatment of Native Glomerular Disease.

Margaret R JorgensonJillian L DescourouezTripti SinghBrad C AstorSarah E Panzer
Published in: Pharmacotherapy (2017)
In our observational study, renal transplant recipients exposed to pretransplantation cyclophosphamide appeared to have a higher risk of developing a malignancy compared with unexposed renal transplant recipients. Further investigation into the impact of pretransplantation immunosuppression on malignancy, particularly the compounded effect with lymphocyte-depleting induction, is warranted.
Keyphrases
  • low dose
  • high dose
  • stem cells
  • peripheral blood
  • mesenchymal stem cells
  • combination therapy
  • endothelial cells