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Inhibition of P21-activated kinase 1 promotes vascular smooth muscle cells apoptosis through reduction of phosphorylation of Bad.

Lin JiaoWenjuan YiYu-Rong ChangWen-Lin ChengJian-Lei CaoSheng-Ping ChaoFang ZhaoZhibing Lu
Published in: American journal of hypertension (2023)
Our study identified that Pak1 acted as a novel regulator of apoptosis of VSMCs partially through phosphorylation of Bad.
Keyphrases
  • vascular smooth muscle cells
  • protein kinase
  • endoplasmic reticulum stress
  • oxidative stress
  • angiotensin ii
  • cell cycle arrest
  • cell death
  • transcription factor
  • tyrosine kinase
  • cell proliferation