Gα12 facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3-kinase-mediated activation in a RhoA-dependent manner.

Edwin J YooGaoyuan CaoCynthia J Koziol-WhiteChristie A OjiakuKrishna SunderJoseph A JudeJames V MichaelHong LamIvan PushkarskyRobert DamoiseauxDino Di CarloKwangmi AhnSteven S AnRaymond B PennReynold A Panettieri

Published in: British journal of pharmacology (2017)

Gα12 plays a crucial role in HASMC contraction via RhoA-dependent activation of the PI3K/ROCK axis. Inhibition of RhoA activation induces bronchodilation in hPCLS, and targeting Gα12 signaling may elucidate novel therapeutic targets in asthma. These findings provide alternative approaches to the clinical management of airway obstruction in asthma.

Keyphrases

smooth muscle
chronic obstructive pulmonary disease
endothelial cells
lung function
allergic rhinitis
tyrosine kinase
air pollution
protein kinase