Idiopathic Pulmonary Fibrosis: The Association between the Adaptive Multiple Features Method and Fibrosis Outcomes.
Margaret L SalisburyDavid A LynchEdwin J R van BeekElla A KazerooniJunfeng GuoMeng XiaSusan MurrayKevin J AnstromEric YowFernando J MartinezEric A HoffmanKevin R Flahertynull nullPublished in: American journal of respiratory and critical care medicine (2017)
More extensive baseline visual and AMFM fibrosis (as measured by GGR densities) is independently associated with elevated hazard for disease progression. Postbaseline change in AMFM-measured and visually measured GGR densities are modestly correlated with change in FVC. AMFM-measured fibrosis is an automated adjunct to existing prognostic markers and may allow for study enrichment with subjects at increased disease progression risk.