Domino Hydroboration/Trifluoromethylation of Alkynes Using Fluoroform-Derived [CuCF3].

Published in: The Journal of organic chemistry (2017)

A domino hydroboration/trifluoromethylation (formal hydrotrifluoromethylation) of alkynes using the fluoroform-derived [CuCF3] reagent is achieved. Synthetically useful (E)-alkenyl-CF3 building blocks and 1,1-bis(trifluoromethyl)-substituted alkenes can be prepared under ambient conditions in one pot/one step from alkynes. The ultimate source of CF3 is the inexpensive industrial waste fluoroform.

Keyphrases

cystic fibrosis
heavy metals
air pollution
particulate matter
molecular docking
ionic liquid
risk assessment
life cycle
anaerobic digestion