MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha.
Amelia FreemanLuhua QiaoNelida OlaveGabriel RezonzewSamuel GentleBrian HalloranGloria S PryhuberAmit GaggarTrent E TippleNamasivayam AmbalavananCharitharth Vivek LalPublished in: Respiratory research (2021)
Taken together, our results demonstrate that increased miR-219-5p contributes to the pathogenesis of BPD by targeting and reducing PDGFR-α. The use of specific miRNA antagonists may be a therapeutic strategy for preventing the development of BPD.
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