Sphingosine 1-phosphate lyase facilitates cancer progression through converting sphingolipids to glycerophospholipids.
Baasanjav UranbilegMakoto KuranoKuniyuki KanoEri SakaiJunichi AritaKiyoshi HasegawaTakeshi NishikawaSoichiro IshiharaHiroharu YamashitaYasuyuki SetoHitoshi IkedaJunken AokiYutaka YatomiPublished in: Clinical and translational medicine (2022)
A new metabolic pathway has been proposed here in HCC and colon cancer, SPL converts S1P to glyceroLPLs, mainly to LPI and LPG, and facilitates cancer development.
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