Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation.

Dongting YaoJiuru ZhaoQianqian ZhangTao WangMeng NiSudong QiQianwen ShenWei LiBaihe LiXiya DingZhiwei Liu

Published in: Cell & bioscience (2022)

Increased Serpine1 expression mediated by DNA demethylation causes lung injury in neonatal mice with IUI. Therefore, therapeutic interventions targeting Serpine1 may effectively prevent IUI-induced lung injury.

Keyphrases

high fat diet induced
oxidative stress
high glucose
physical activity
diabetic rats
circulating tumor
genome wide
cell free
type diabetes
metabolic syndrome
drug induced
skeletal muscle
adipose tissue
drug delivery
long non coding rna
nucleic acid