Identification of RNPC3 as a novel JAK2 fusion partner gene in B-acute lymphoblastic leukemia refractory to combination therapy including ruxolitinib.

Xue ChenFang WangYang ZhangXiaoli MaMingyue LiuPanxiang CaoLin ZhouLan WangXian ZhangTong WangHongxing Liu

Published in: Molecular genetics & genomic medicine (2019)

This finding adds to the expanding compendium of JAK2 fusions found in B-ALL and suggests the potential need for a diagnostic FISH analysis as well as RNA-Seq in the appropriate clinical setting.

Keyphrases

rna seq
combination therapy
acute lymphoblastic leukemia
single cell
allogeneic hematopoietic stem cell transplantation
genome wide
copy number
gene expression
acute myeloid leukemia
transcription factor
risk assessment
climate change
hiv testing
bioinformatics analysis
hiv infected