Mechanism of Sanguinarine in Inhibiting Macrophages to Promote Metastasis and Proliferation of Lung Cancer via Modulating the Exosomes in A549 Cells.

Yuanyuan YuYingbin LuoZhihong FangWenjing TengYongchun YuJianhui TianPeng GuoRongzhong XuJian-Chun WuYan Li

Published in: OncoTargets and therapy (2020)

Exosomes treated by SNG inhibited THP-1 cells so that the invasion, proliferation, and migration of A549 cells were inhibited, and the apoptosis was promoted. The mechanism is possibly associated with the inhibition of NF-κB pathway in THP-1 cells.

Keyphrases

cell cycle arrest
induced apoptosis
signaling pathway
cell death
endoplasmic reticulum stress
oxidative stress
stem cells
mesenchymal stem cells
cell proliferation
immune response
toll like receptor