Rifampicin and protein concentrations in paired spinal versus ventricular cerebrospinal fluid samples of children with tuberculous meningitis.

Jill M CombrinckPhophi TshavhungweUrsula K RohlwinkNico EnslinNqobile ThangoJed LazarusKatie KrieglerSandra CastelNoha AbdelgawadHelen McilleronPaolo Denti Lubbe WiesnerAnthony Figaji

Published in: The Journal of antimicrobial chemotherapy (2024)

Total protein and rifampicin concentrations differed significantly between the two compartments, both being higher in LCSF than in VCSF samples (P < 0.0001 for total protein and P = 0.0046 for rifampicin). Further studies are required to explore the causative reasons for the observed differences.

Keyphrases

cerebrospinal fluid
mycobacterium tuberculosis
protein protein
pulmonary tuberculosis
heart failure
binding protein
spinal cord
left ventricular
small molecule