Impact of body mass index on outcome and treatment-related toxicity in young adults with acute lymphoblastic leukemia.
Christina EgnellHelene HallböökMats HeymanUlla Wartiovaara-KauttoPetter Quist-PaulsenKjeld SchmiegelowLaimonas GriskeviciusKatrin PalkNina ToftUlrik Malthe OvergaardArja HarilaSusanna RantaPublished in: Acta oncologica (Stockholm, Sweden) (2023)
Severe obesity is associated with worse EFS in young adults treated according to the non-HR arms of the NOPHO ALL2008 protocol. Poorer outcome is explained with a higher risk of relapse, possibly due to under treatment, and not caused by excess therapy-related mortality.
Keyphrases
- young adults
- acute lymphoblastic leukemia
- body mass index
- type diabetes
- weight gain
- oxidative stress
- physical activity
- insulin resistance
- stem cells
- coronary artery disease
- combination therapy
- early onset
- adipose tissue
- mesenchymal stem cells
- allogeneic hematopoietic stem cell transplantation
- acute myeloid leukemia
- newly diagnosed
- cell therapy
- free survival
- childhood cancer