Multiscale heterogeneity of white matter morphometry in psychiatric disorders.

Ashlea Segal Robert E Smith Sidhant Chopra Stuart Oldham Linden Parkes Kevin M Aquino Seyed Mostafa Kia Thomas Wolfers Barbara Franke Martine Hoogman Christian F Beckmann Lars Tjelta Westlye Ole Andreas AndreassenAndrew ZaleskeyHarrison J BenChristopher G Davey Carles Soriano-Mas Narcís Cardoner Jeggan TiegoMurat YucelLeah BraganzaChao SuoMichael BerkSusan M Cotton Mark A Bellgrove Andre F Marquand Alex Fornito

Published in: bioRxiv : the preprint server for biology (2024)

The prevalence of white matter volume deviations was lower than previously observed in grey matter, and the specific location of these deviations was highly heterogeneous when considering voxelwise spatial resolution. Evidence of aggregation within common pathways and networks was apparent in schizophrenia and autism but not other disorders.

Keyphrases

white matter
multiple sclerosis
bipolar disorder
autism spectrum disorder
risk factors
intellectual disability
single cell
single molecule
diffusion weighted imaging
computed tomography
magnetic resonance