Population pharmacokinetics and dose optimisation of colecalciferol in paediatric patients with chronic kidney disease.
Mandy WanBruce GreenArpana Aprameya IyengarNivedita KamathHamsa V ReddyJyoti SharmaJyoti SinghalSusan UthupSudha EkambaramSumithra SelvamGreta RaitRukshana ShroffJignesh P PatelPublished in: British journal of clinical pharmacology (2021)
This is the first study to describe the population PK of colecalciferol in children with CKD. PK model informed dosing is expected to improve the attainment of target 25(OH)D concentrations, while minimising the risk of overdosing.