Clinical Response to Third-Line Angiotensin-II vs Epinephrine in Septic Shock: A Propensity-Matched Cohort Study.

Caitlyn R BlankenshipKevin D BetthauserLaura N HenckenJulie A MaamariJenna GoetzBria D GiacominoGabrielle A Gibson

Published in: The Annals of pharmacotherapy (2024)

Administration of AT-II as a third-line vasopressor agent in septic shock patients was not associated with significantly improved clinical response at hour 24 compared with epinephrine. Although underpowered to detect meaningful differences, the clinical observations of this study warrant consideration and further investigation of AT-II as a third-line vasopressor in septic shock.

Keyphrases

septic shock
angiotensin ii
newly diagnosed
ejection fraction
end stage renal disease
blood pressure
vascular smooth muscle cells
patient reported