Nanoselenium improved learning, memory, and brain-derived neurotrophic factor and attenuated nitric oxide, and oxidative stress in the brain of juvenile hypothyroid rats.
Fatemeh Hojjati FardFereshteh SabziNarges MarefatiFarzaneh VafaeeFarimah BeheshtiAlireza HashemzadehMajid DarroudiMahmoud HosseiniPublished in: Metabolic brain disease (2022)
It is concluded that Nan S might be able to enhance endogenous antioxidant proteins due to its antioxidant activity, thereby improving BDNF and spatial and avoidance memory in the hypothyroidism-induced memory impairment model however, more studies are still necessary to elucidate the exact mechanism(s).
Keyphrases
- oxidative stress
- nitric oxide
- working memory
- diabetic rats
- high glucose
- ischemia reperfusion injury
- hydrogen peroxide
- induced apoptosis
- density functional theory
- brain injury
- subarachnoid hemorrhage
- endothelial cells
- replacement therapy
- cerebral ischemia
- molecular dynamics
- functional connectivity
- heat stress
- heat shock protein
- endoplasmic reticulum stress