Potential role of oxidative stress in the pathogenesis of diabetic bladder dysfunction.
Qi-Xiang SongYi SunKangli DengJin-Yi MeiChristopher J ChermanskyMargot S DamaserPublished in: Nature reviews. Urology (2022)
Diabetes mellitus is a chronic metabolic disease, posing a considerable threat to global public health. Treating systemic comorbidities has been one of the greatest clinical challenges in the management of diabetes. Diabetic bladder dysfunction, characterized by detrusor overactivity during the early stage of the disease and detrusor underactivity during the late stage, is a common urological complication of diabetes. Oxidative stress is thought to trigger hyperglycaemia-dependent tissue damage in multiple organs; thus, a growing body of literature has suggested a possible link between functional changes in urothelium, muscle and the corresponding innervations. Improved understanding of the mechanisms of oxidative stress could lead to the development of novel therapeutics to restore the redox equilibrium and scavenge excessive free radicals to normalize bladder function in patients with diabetes.
Keyphrases
- oxidative stress
- type diabetes
- public health
- early stage
- spinal cord injury
- glycemic control
- dna damage
- diabetic rats
- urinary tract
- ischemia reperfusion injury
- induced apoptosis
- cardiovascular disease
- botulinum toxin
- systematic review
- wound healing
- skeletal muscle
- molecular dynamics simulations
- squamous cell carcinoma
- insulin resistance
- weight gain
- heat shock
- body mass index
- radiation therapy
- signaling pathway
- lymph node