Increased Risk of Stroke Due to Non-adherence and Non-persistence with Direct Oral Anticoagulants (DOACs): Real-World Analyses Using a Nested Case-Control Study from The Netherlands, Italy and Germany.
Emily HolthuisElisabeth SmitsGeorge SpentzourisDominik BeierDirk EndersRosa GiniClaudia BartoliniGiampiero MazzagliaFernie J A Penning-van BeestRon M C HeringsPublished in: Drugs - real world outcomes (2022)
Both non-adherence (in Germany) and non-persistence increased the risk of stroke, either using a once-daily or twice-daily regime.