Identification and characterization of novel candidate compounds targeting 6- and 7-transmembrane μ-opioid receptor isoforms.
Arjun MuralidharanAlexander SamoshkinMarino ConvertinoMarjo Hannele PiltonenPavel GrisJian WangChangyu JiangRichard KlaresAlexander A LintonRu-Rong JiWilliam MaixnerNikolay V DokholyanJeffrey S MogilLuda DiatchenkoPublished in: British journal of pharmacology (2021)
Our novel compounds represent a new class of ligands for μ receptors and will serve as valuable research tools to facilitate the development of opioids with significant analgesic efficacy and fewer side-effects.