Acute to long-term characteristics of impedance recordings during neurostimulation in humans.

Jie Cui Filip Mivalt Vladimir SladkyJiwon KimThomas J Richner Brian Nils LundstromJamie J Van GompelHai-Long Wang Kai J Miller Nicholas M Gregg Long Jun Wu Timothy J Denison Bailey Winter Benjamin H Brinkman Vaclav Kremen Gregory A Worrell

Published in: medRxiv : the preprint server for health sciences (2024)

Our findings illustrate the complex temporal dynamics of impedance in implanted electrodes and the impact of electrical stimulation. We discuss these dynamics in the context of the known biological foreign body response of the brain to implanted electrodes. The data suggest that the temporal dynamics of impedance are dependent on the anatomical location and tissue epileptogenicity. These insights may offer additional guidance for the delivery of therapeutic stimulation at various time points post-implantation for neuromodulation therapy.

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