Determination and pharmacokinetic study of AZD-3759 in rat plasma by ultra performance liquid chromatography with triple quadrupole mass spectrometer.

Qingjun WuAilian HuaYaoguang SunChao MaWenxin TianChuan HuangHanbo YuPeng JiaoShuanghu WangHongfeng TongWeiwen Qiu

Published in: Thoracic cancer (2018)

An accurate, simple ultra performance liquid chromatography with triple quadrupole mass spectrometer method was developed and validated to determine AZD-3759 in rat plasma. Our validated method can be applied to the pharmacokinetic study of AZD-3759 at an oral dosage of 10 mg/kg.

Keyphrases

liquid chromatography
high resolution
mass spectrometry
tandem mass spectrometry
solid phase extraction
high resolution mass spectrometry
high performance liquid chromatography
simultaneous determination
gas chromatography
molecularly imprinted