X chromosome escapee genes are involved in ischemic sexual dimorphism through epigenetic modification of inflammatory signals.

Shaohua QiAbdullah Al MamunConelius NgwaSharmeen RomanaRodney RitzelArthur P ArnoldLouise D McCulloughFudong Liu

Published in: Journal of neuroinflammation (2021)

The KDM-Histone-IRF pathways are suggested to mediate sex differences in cerebral ischemia. Epigenetic modification of stroke-related genes constitutes an important mechanism underlying the ischemic sexual dimorphism.

Keyphrases

cerebral ischemia
dna methylation
subarachnoid hemorrhage
genome wide
blood brain barrier
brain injury
gene expression
mental health
copy number
oxidative stress
atrial fibrillation
immune response
ischemia reperfusion injury
bioinformatics analysis