Plasma extracellular nanovesicle (exosome)-derived biomarkers for drug metabolism pathways: a novel approach to characterize variability in drug exposure.

Andrew RowlandWarit RuanglertboonMadelé van DykDhilushi WijayakumaraLinda S WoodRobyn MeechPeter I MackenzieA David RodriguesJean-Claude MarshallMichael J Sorich

Published in: British journal of clinical pharmacology (2018)

Consistent strong concordance was observed between exosome-derived CYP3A4 biomarkers and midazolam CL/F. The significance of these results is that CYP3A4 is the drug-metabolizing enzyme of greatest clinical importance and variability in CYP3A4 activity is poorly described by existing precision dosing strategies.

Keyphrases

adverse drug
drug induced
emergency department